Description
The antibody binds both mouse and human dendritic cells (DC) in a B7-DC (PD-L2)-dependent manner. Systemic treatment of experimental animals with this antibody induces potent anti-melanoma immunity and modulates protectively the recall response against antigen challenge through the airway in an experimental model of inflammatory airway disease.
Target
DC Cell
Target Alias Names
Dendritic cell, DC
Isotype/Mimetic
Human IgM
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression