Description
SARS-Cov-2 Spike Protein (CR3022 Chimeric) Mouse IgG2a mAb recognizes an epitope in the receptor binding domains (RBDs) of SARS-CoV-2 and SARS-CoV spike proteins. SARS-CoV-2 Spike Protein (CR3022 Chimeric) Mouse IgG2a mAb has been reported to bind to both wild-type and P462L-mutant versions of the SARS spike protein. The epitope is only accessible in the "open" conformation of the spike protein (10-13). Monoclonal antibody was derived from a monoclonal antibody generated semi-synthetically from a patient infected with SARS-CoV (14).
Target
Spike Protein SARS-CoV-2
Target Alias Names
S, Spike Glycoprotein
Isotype/Mimetic
IgG2a
Animal-Derived Biomaterials Used
BSA
Sequence Available
Yes
Original Discovery Method
Immunization
Antibody/Binder Origins
Animal-dependent discovery, post-2020, In vitro recombinant expression, Animal-derived biomaterials used in production or final formulation